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KMID : 1001920100470050325
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Journal of Korean Neurosurgical Society
2010 Volume.47 No. 5 p.325 ~ p.331
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Little Response of Cerebral Metastasis from Hepatocellular Carcinoma to Any Treatments
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Han Jung-Ho
Kim Dong-Gyu
Park Jung-Cheol
Chung Hyun-Tai
Paek Sun-Ha
Chung Young-Seob
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Abstract
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Objective: We retrospectively evaluated the survival outcome of patients with brain metastasis from hepatocellular carcinoma (HCC).
Methods: Between 1991 and 2007, a total of 20 patients were diagnosed as having brain metastasis from HCC. The mean age of the patients was 55 ± 13 years, and 17 (85.0%) were men. Seventeen (85.0%) patients had already extracranial metastases. The median time from diagnosis of HCC to brain metastasis was 18.5 months. Fourteen (70.0%) patients had stroke-like presentation due to intracerebral hemorrhage (ICH). Ten (50.0%) patients had single or solitary brain metastasis. Among a total of 34 brain lesions, 31 (91.2%) lesions had the hemorrhagic components.
Results: The median survival time was 8 weeks (95% CI, 5.08-10.92), and the actuarial survival rates were 85.0%, 45.0%, 22.5%, and 8.4% at 4, 12, 24, and 54 weeks. Age < 60 years, treatment of the primary and/or extracranial lesions, and recurrent ICH were the possible prognostic factors (p = 0.044, p < 0.001, and p = 0.111, respectively). The median progression-free survival (PFS) time was 3 months (95% CI, 0.95-5.05).
Conclusion: The overall survival of the patients with brain metastasis from HCC was very poor with median survival time being only 8 weeks. However, the younger patients less than 60 years and/or no extracranial metastases seem to be a positive prognostic factor.
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KEYWORD
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Brain metastasis, Hepatocellular carcinoma, Survival outcome, Prognostic factor
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